Methods for high-resolution genome-wide functional dissection of transcriptional regulatory regions
US11987790B2 · kind B2 · utility
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Key dates
| Filing date | Oct 17, 2018 |
| Grant date | May 21, 2024 |
| Priority date | — |
| Expiry date | Jan 10, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.