Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

US11993606B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Mohamed-Eslam F. Mohamed · Gurnee, US
• Ahmed A. Othman · Libertyville, US
• Aileen L. Pangan · La Grange, US
• In-Ho Song · Vernon Hills, US
• Ben Klünder · Ludwigshafen, DE
• Jeffrey W. Voss · Hudson, US
• Robert J. Padley · Highland Park, US
• Heidi S. Camp · Winnetka, US

Key dates

• Filing date: Aug 21, 2023
• Grant date: May 28, 2024
• Expiry date: Aug 21, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).