Patent · US Active

Compositions comprising R-Spondin (RSPO) surrogate molecules

US11993645B2 · kind B2 · utility

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8References

10Claims

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Assignee

The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Vincent Luca · Saint-Fons, FR
Kenan Christopher Garcia · Menlo Park, US

Key dates

Filing date	Jan 11, 2018
Grant date	May 28, 2024
Priority date	—
Expiry date	Mar 6, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/81
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.