Low-viscosity antigen binding proteins and methods of making them
US11993663B2 · kind B2 · utility
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7References
12Claims
0Family size
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Key dates
| Filing date | Jun 11, 2021 |
| Grant date | May 28, 2024 |
| Priority date | — |
| Expiry date | Feb 9, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N11/14
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.