Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against multidrug and extensively drug-resistant Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates
US11998560B2 · kind B2 · utility
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Key dates
| Filing date | Nov 22, 2019 |
| Grant date | Jun 4, 2024 |
| Priority date | — |
| Expiry date | Feb 20, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Herein, we describe the development of non-β-lactam-based potentiator molecules that synergize with β-lactam antibiotics and β-lactam-β-lactamase inhibitor combinations against MDR/XDR P. aeruginosa phenotypes. The compound comprises a chemical structure or chemical formula of Formula (A) or a suitable salt form thereof, wherein “n” is a carbon tether having a length of between about 2-18 carbons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.