Conjugate of a tubulysin analog with branched linkers
US11998584B2 · kind B2 · utility
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Key dates
| Filing date | Dec 31, 2017 |
| Grant date | Jun 4, 2024 |
| Priority date | — |
| Expiry date | Oct 2, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1024
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.