Self-assembling antiviral prodrugs

US11998609B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Honggang Cui · Timonium, US
• Charles Williams Flexner · Baltimore, US
• Maya Monroe · Baltimore, US
• Han Wang · Beijing, CN

Key dates

• Filing date: Nov 7, 2022
• Grant date: Jun 4, 2024
• Expiry date: Nov 7, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are therapeutic self-assembling molecules including a peptide sequence conjugated to one or more antiviral therapeutics to form a peptide-based antiviral prodrug capable of self-assembly into supramolecular structures with varying morphology in aqueous solutions, which can be injected subcutaneously or intramuscularly for the long-acting treatment of chronic viral infections.