Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof
US11998613B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jun 4, 2021 |
| Grant date | Jun 4, 2024 |
| Priority date | — |
| Expiry date | Sep 16, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.