Compositions and methods for selective protein degradation

US11999802B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• James E. Bradner · Weston, US
• Andrei Golosov · Cambridge, US
• Carleton Proctor Goold · Watertown, US
• Carla Guimaraes · Boston, US
• Marc Horst Peter Hild · Wellesley, US
• Gregory Motz · Cambridge, US
• Nathan Ross · Cambridge, US
• Jonathan M. Solomon · Somerville, US
• Rohan Eric John Beckwith · Cambridge, US
• Seth Carbonneau · Brookline, US

Key dates

• Filing date: Oct 18, 2018
• Grant date: Jun 4, 2024
• Expiry date: Jun 14, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/15043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.