Probiotic method and composition for maintaining a healthy vaginal microbiome
US12005085B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2023 |
| Grant date | Jun 11, 2024 |
| Priority date | — |
| Expiry date | Aug 10, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of at least two live bacteria selected from the group consisting of L. reuteri, L johnsonii and L. crispatus, and at least one prebiotic having glycogen as a component thereof. The bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina. Certain embodiments include increasing the production of SCFAs in the individual's gut microbiome, while reducing the production of SCFAs in the individual's vagina and introducing ammonia oxidizing microorganisms to the individual's vagina.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.