Patent · US Active

Salts of obicetrapib and processes for their manufacture and intermediates thereof

US12006305B2 · kind B2 · utility

0Cited by

9References

27Claims

0Family size

Assignee

NewAmsterdam Pharma B.V. · NL

Inventors

Sheng Cui · Lexington, US
Andreas René Rötheli · Wellesley, US
Christopher J. BORTHS · Dogwood Place, US
Muneki Kishida · Osaka, JP

Key dates

Filing date	Jul 3, 2023
Grant date	Jun 11, 2024
Priority date	—
Expiry date	Jul 3, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein is a method for the manufacture of a compound of obicetrapib and salts thereof, such as calcium salts thereof. Also provided herein is amorphous obicetrapib hemicalcium. New intermediates for use in the synthesis of obicetrapib, and salts thereof are also provided, including obicetrapib HCl and a mesylate salt for the use in the synthesis of obicetrapib and amorphous obicetrapib hemicalcium.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.