CD206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker
US12006339B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 19, 2023 |
| Grant date | Jun 11, 2024 |
| Priority date | — |
| Expiry date | May 19, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65397
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are novel compounds containing a polymeric carbohydrate backbone, one or more mannose-binding C-type lectin receptor targeting moieties, and a nitrogenous bisphosphonate compound coupled to the backbone via a thiol-maleimide conjugation, in addition to pharmaceutical compositions, methods of synthesizing, and methods of use. The thiol-maleimide conjugation of a bisphosphonate to a polymeric carbohydrate backbone provides for methods of using the compounds and compositions thereof for releasing the therapeutic payload when internalized into a mannose-binding C-type lectin receptor-expressing cell, such as tumor associated macrophages (TAMs) for the treatment of various diseases, including, cancer, autoimmune diseases, and inflammatory disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.