Production of RNA by yeasts with recombinant pseudo-viral particles
US12006525B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 21, 2018 |
| Grant date | Jun 11, 2024 |
| Priority date | — |
| Expiry date | Feb 18, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y207/07006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The application relates to the production of RNA of interest, more specifically of messenger RNA of interest or of long non-coding RNA of interest, by yeasts with recombinant pseudo-viral particles. The recombinant yeasts have been genetically modified in order to produce the RNA of interest in the form of a complex, particularly in the form of recombinant pseudo-viral particles. These recombinant pseudo-viral particles are produced from certain elements of yeast Ty retrotransposon, but do not retrotranscribe the RNA that they contain. Thus, the application relates to the components that are thus capable of being implemented or produced, and particularly to the nucleic acid constructs, kits, bacteria cells, yeast cells, culture or transfection media containing them, as well as to a method for producing a pharmaceutical composition, particularly for medical applications, more specifically for vaccines, anti-tumour and pro-regenerative applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.