Rapid detection and identification of bacteria with graphene field effect transistors and peptide probes

US12007354B2 · kind B2 · utility

Assignee

• The Trustees of Boston College · US

Inventors

• Kenneth S. Burch · Watertown, US
• Tim van Opijnen · Somerville, US
• Jianmin Gao · Newton, US
• Narendra Kumar · Ongole, IN
• Juan C. Ortiz-Marquez · Watertown, US
• Wenjian Wang · Nanhu, CN
• Mason Gray · East Sharon, US

Key dates

• Filing date: Nov 6, 2020
• Grant date: Jun 11, 2024
• Expiry date: Nov 6, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/4148
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.