High concentration anti-C5 antibody formulations
US12012448B2 · kind B2 · utility
1Cited by
56References
13Claims
0Family size
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Key dates
| Filing date | Dec 21, 2022 |
| Grant date | Jun 18, 2024 |
| Priority date | — |
| Expiry date | Dec 21, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to stable aqueous solutions comprising a high concentration of an anti-05 antibody (e.g., ravulizumab) and methods for preparing the solutions. The disclosure also provides methods for treating or preventing complement-associated disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), using the solutions. Also featured were therapeutic kits containing one or more of the solutions and a means for administering the solutions to a patient in need such a treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.