Dual-network collagen-based supramolecular hydrogel and its preparation method

US12012488B2 · kind B2 · utility

Assignee

• SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY · CN

Inventors

• Jiabo Shi · Xi'an, CN
• Yuxuan Zhang · Lexington, US
• Jikai Yang · Xi'an, CN
• Ruizhen ZHANG · Shanghai, CN
• Yuxin DU · Lo Wu, CN
• Xinchun Chen · Xi'an, CN

Key dates

• Filing date: Jun 27, 2023
• Grant date: Jun 18, 2024
• Expiry date: Jun 27, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K2201/011
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

Disclosed is a preparation method of a dual-network collagen-based supramolecular hydrogel, including: preparing a silicate nanosheet dispersion and a collagen solution separately; mixing the silicate nanosheet dispersion with the collagen solution followed by stirring to obtain a collagen-silicate nanosheet network; preparing a tannic acid solution and a polyethylene glycol solution separately; mixing the tannic acid solution with the polyethylene glycol solution to obtain a polyethylene glycol-tannic acid network; and subjecting the collagen-silicate nanosheet network and the polyethylene glycol-tannic acid network to reaction to obtain the dual-network collagen-based supramolecular hydrogel. A dual-network collagen-based supramolecular hydrogel prepared by such method is also provided.