Peptide library constructing method and related vectors
US12012595B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 3, 2015 |
| Grant date | Jun 18, 2024 |
| Priority date | — |
| Expiry date | Apr 1, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved peptide library preparation method is described for constructing complete peptide libraries such as a complete tripeptide library, tetrapeptide library, pentapeptide library, hexapeptide library, heptapeptide library, or a complete octapeptide library, etc. The method includes constructing an expression vector for the expression of tagged peptides. Each tagged peptide contains an array of peptides of different sizes, and the number of peptides in a complete peptide library can be dramatically reduced relative to conventional chemical peptide synthesis. Furthermore, the libraries can be readily reproduced. The improved peptide library preparation method can particularly be used, for example, to construct a complete pentapeptide library. Other related methods and related expression vectors are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.