Manipulated immunoregulatory element and immunity altered thereby
US12012598B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Aug 14, 2017 |
| Grant date | Jun 18, 2024 |
| Priority date | — |
| Expiry date | Apr 1, 2040 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.