Tissue catalyzed growth of polymer as epithelial linings for therapy

US12016901B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Robert S. Langer · Newton, US
• Carlo Giovanni Traverso · Newton, US
• Junwei Li · Beijing, CN
• Thomas D. Wang · Lexington, US
• Ameya R. Kirtane · Minneapolis, US
• Yunhua Shi · Singapore, SG

Key dates

• Filing date: Dec 10, 2020
• Grant date: Jun 25, 2024
• Expiry date: Jan 16, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y111/01006
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.