Claudin 18.2 T cell-antigen couplers and uses thereof
US12016923B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jun 1, 2022 |
| Grant date | Jun 25, 2024 |
| Priority date | — |
| Expiry date | Jun 1, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Claudin 18.2 T cell antigen couplers (TACs) polypeptides having (i) an antigen-binding domain that binds Claudin 18.2, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided. Nucleic acids encoding the claudin 18/2 TACs are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.