Patent · US Active

Gene editing for hemophilia A with improved factor VIII expression

US12016932B2 · kind B2 · utility

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Key dates

Filing dateNov 15, 2022
Grant dateJun 25, 2024
Priority date
Expiry dateNov 15, 2042

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2800/22
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.