Patent · US Active

Method for stimulating axonal regeneration

US12016933B2 · kind B2 · utility

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5Claims

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Assignee

The Hong Kong University of Science and Technology

Inventors

Chao-Yie Yang · Hangzhou City, CN
Xu Wang · 安丰镇, CN
Kai Liu · Nanhu, CN

Key dates

Filing date	Nov 25, 2020
Grant date	Jun 25, 2024
Priority date	—
Expiry date	Nov 11, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2750/14143
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method of promoting axonal regeneration can include directing neuronal lipid synthesis away from triglyceride synthesis and toward phospholipid synthesis. The method can include administering to the patient a therapeutically effective amount of an inhibitor compound selected from the group consisting of a Lipin-1 inhibitor, a diglyceride acyltransferase inhibitor, and combinations thereof or administering a gene editing therapy to the patient that reduces expression of LIPIN1 or a diglyceride acyltransferase gene.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.