Preparation method of Cu—Pd—CeO2/γ—Al2O3@NP catalyst and synthesis method of benzopyrazine compounds

US12017206B2 · kind B2 · utility

Assignee

• ZHEJIANG UNIVERSITY OF TECHNOLOGY · CN

Inventors

• Feng Feng · South Windsor, US
• Xiaonian Li · Zhejiang, CN
• Lingling GUO · Wuxi, CN
• Yanxia Sun · Solo Court, CN
• Chunshan Lu · Zhejiang, CN
• Qunfeng Zhang · Zhejiang, CN
• Jiatong Jin · Zhejiang, CN
• Xiaoliang Xu · Shanghai, CN

Key dates

• Filing date: Sep 28, 2022
• Grant date: Jun 25, 2024
• Expiry date: Jan 7, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/42
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A preparation method of Cu—Pd—CeO2/γ-Al2O3@NP catalyst and a synthesis method of benzopyrazine compounds. The preparation method of the Cu—Pd—CeO2/γ-Al2O3@NP catalyst comprises the following steps: (1) preparing a CeO2/γ-Al2O3 carrier; (2) preparing a CeO2/γ-Al2O3@NP carrier; (3) preparing the Cu—Pd—CeO2/γ-Al2O3@NP catalyst by impregnation method. A one-pot method for synthesizing benzopyrazine compounds of formula (III) includes using an o-nitroaniline compound of formula (I) and an aliphatic diol compound of formula (II) as raw materials, carrying out the one-pot synthesis of the benzopyrazine compound of formula (III) under solvent-free condition and under the combined action of the Cu—Pd—CeO2/γ-Al2O3@NP catalyst prepared by the method and an alkali. The Cu—Pd—CeO2/γ-Al2O3@NP catalyst increases the number of basic sites by doping N and P, and meanwhile loads CeO2 to assist in the extraction of protons, thereby improving the dehydrogenation activity and product selectivity.