Patent · US Active

Macrocyclic derivatives acting as XIa factor inhibitor

US12018027B2 · kind B2 · utility

0Cited by

0References

20Claims

0Family size

Assignee

China Resources Biopharmaceutical Company Limited · CN

Inventors

Yaxian Cai · Shanghai, CN
Xiaobing Yan · Baoding, CN
Ting Wang · Beijing, CN
Chengde Wu · Shanghai, CN
Charles Z. Ding · San Mateo, US
Shuhui CHEN · Shanghai, CN

Key dates

Filing date	Apr 15, 2020
Grant date	Jun 25, 2024
Priority date	—
Expiry date	Jul 29, 2041

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are a class of macrocyclic derivatives, a preparation method therefor, a pharmaceutical composition containing the derivatives, and the use thereof as therapeutic agents, particularly as XIa factor inhibitors and in the preparation of a drug for treating and preventing thromboembolisms and other diseases. Particularly disclosed are compounds shown by formula (I), an isomer thereof and a pharmaceutically acceptable salt thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.