Methods for chemically induced lineage reprogramming
US12018278B2 · kind B2 · utility
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Key dates
| Filing date | May 31, 2017 |
| Grant date | Jun 25, 2024 |
| Priority date | — |
| Expiry date | Feb 2, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are chemical inducers of lineage reprogramming (CiLR) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists or histone acetylators. Also provided is a method of inducing lineage reprograming in a partially or completely differentiated cell of a first type into a cell with characteristics of a second and different lineage. The method includes: contacting a cell with the CiLR for a sufficient period of time to result in reprograming the cell into a modified XEN-like cell which is subsequently programmed into a cell with characteristics of a second and different lineage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.