Method for producing insulin-producing cells
US12018283B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 24, 2019 |
| Grant date | Jun 25, 2024 |
| Priority date | — |
| Expiry date | Feb 28, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1307
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention chiefly aims to provide a process for directly inducing insulin-producing cells from somatic cells without performing artificial gene transfer. The present invention can include a process for producing an insulin-producing cell by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a cAMP inducer, and six members selected from the group consisting of a GSK3 inhibitor, a TGF-β inhibitor, a BMP inhibitor, a p53 inhibitor, a PI3K inhibitor, a Notch inhibitor and a RAR agonist, or all members thereof. The insulin-producing cells obtained by the present invention are useful in regenerative medicine and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.