Method for preparing amines from carbonyl compounds by transaminase reaction under salt precipitation

US12018303B2 · kind B2 · utility

Assignee

• Enzymicals AG · DE

Inventors

• Jan Von Langermann · Rostock, DE
• Dennis Hülsewede · Rostock, DE
• Marco Cornelius · Potsdam, DE
• Ulf Menyes · Neu Boltenhagen, DE
• Philipp Süss · Greifswald, DE

Key dates

• Filing date: Nov 16, 2018
• Grant date: Jun 25, 2024
• Expiry date: Sep 18, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/40
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).