3′-O-modified nucleotide analogues with different cleavable linkers for attaching fluorescent labels to the base for DNA sequencing by synthesis

US12018325B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jingyue Ju · Englewood Cliffs, US
• Xiaoxu Li · New York, US
• Xin Chen · Lexington, US
• Shiv Kumar · Montgomery, US
• James J. Russo · New York, US
• Minchen Chien · Tenafly, US

Key dates

• Filing date: Mar 28, 2018
• Grant date: Jun 25, 2024
• Expiry date: May 21, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.