Use of manzamines as antiproliferative agent
US12023330B2 · kind B2 · utility
0Cited by
0References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 2021 |
| Grant date | Jul 2, 2024 |
| Priority date | — |
| Expiry date | Feb 6, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods and systems for using an alkaloid, such as manzamine A, for anti-proliferative effects at relatively low and non-cytotoxic concentrations (up to 4 μM) wherein manzamine A blocks cell cycle progression in cervical cancer cell lines and regulates cell cycle-related genes, including restoration of p21 and p53 expression inducing apoptosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.