Isomerically pure 18F-labelled tetrahydrofolates
US12023390B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Mar 19, 2018 |
| Grant date | Jul 2, 2024 |
| Priority date | — |
| Expiry date | Oct 25, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed towards isomerically pure 18F-labelled (6S)- or (6R)-5-methyltetrahydrofolate radiopharmaceuticals, wherein the phenyl group within the folate structure, has been replaced by an 18F-labelled N-heterocycle, for use in diagnostic imaging of a cell or population of cells expressing a folate-receptor in vitro or in vivo or for use in monitoring of cancer or inflammatory and autoimmune diseases and therapy thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.