Dihydroquinazolinones exhibiting protective activity against intracellular-acting toxins, intracellular viruses and bacteria
US12024508B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Nov 28, 2019 |
| Grant date | Jul 2, 2024 |
| Priority date | — |
| Expiry date | Jul 28, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a new family of compounds of the type 2,3-dihydroquinazolin-4(1H)-one and the use thereof as inhibitors of the toxic effects of intracellular-acting toxins, such as ricin, Shiga toxins or the cholera toxin, using retrograde transport to intoxicate the cells, or viruses or bacteria using retrograde and/or syntaxin 5-dependent transport to infect the cells, specifically viruses or bacteria entering into the cells by means of endocytosis, or intracellular parasites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.