Antiproliferative compounds and methods of use thereof

US12029738B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Matthew D. Alexander · San Diego, US
• Gerald D. Artman, III · Asbury, US
• Gordon L. Bray · San Francisco, US
• James Carmichael · Nottingham, GB
• Soraya Carrancio · San Diego, US
• Brian E. Cathers · San Diego, US
• Matthew D. Correa · San Diego, US
• Joshua Hansen · Village of La Jolla, US
• Courtney G. Havens · San Diego, US
• Timothy Kercher · Longmont, US
• Antonia Lopez-Girona · San Diego, US
• Xiaoling Lu · Whippany, US
• Hon-Wah Man · Princeton, US
• Mark A. Nagy · San Diego, US
• Rama Krishna Narla · San Diego, US
• Joseph R. Piccotti · Encinitas, US
• Daniel W. Pierce · Belmont, US
• Paula A. Tavares-Greco · Parsippany, US
• Brandon W. Whitefield · San Diego, US
• Lilly L. Wong · Solana Beach, US
• Nanfei Zou · Fanwood, US

Key dates

• Filing date: Nov 8, 2021
• Grant date: Jul 9, 2024
• Expiry date: Nov 8, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.