Guidance and Navigation Control proteins and method of making and using thereof

US12029761B2 · kind B2 · utility

Assignee

• SystImmune, Inc. · US

Inventors

• Yi Zhu · Chengdu, CN
• Ole Olsen · Everett, US
• Dong Xia · Redmond, US
• David Jellyman · Duvall, US
• Katrina Bykova · Seattle, US
• Anne-Marie K. Rousseau · Seattle, US
• Bill Brady · Watertown, US
• Blair R. Renshaw · Renton, US
• Brian R. Kovacevich · Snohomish, US
• Yu Liang · Tokyo, JP
• Camilla Wang · Sammamish, US
• Zeren Gao · Redmond, US
• Hui Huang · Redmond, US

Key dates

• Filing date: Mar 26, 2019
• Grant date: Jul 9, 2024
• Expiry date: Aug 15, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).