Three-dimensional bioprinting of cardiac patch with anisotropic and perfusable architecture
US12029832B2 · kind B2 · utility
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Key dates
| Filing date | Apr 10, 2020 |
| Grant date | Jul 9, 2024 |
| Priority date | — |
| Expiry date | Aug 14, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29L2031/7546
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A cardiac patch for treatment of a mammalian heart including perfusable vessels embedded integratedly between two layers of anisotropically oriented myocardial fibers. The cardiac patch is made using a dual 3D bioprinting technique using stereolithography to form an anisotropic construct and extrusion printing to form perfusion vessels. A nutrient and oxygen containing media can be provided within the perfusion vessels for growth of cells in the cardiac patch. The technique permits larger patches to be made for the treatment of cardiac damage in both small and large mammalian hearts.
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