Anti-idiotypic antibodies against anti-GPRC5D antibodies

US12030937B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Ellen Chi · San Diego, US
• Wilson Edwards · Encinitas, US
• Matt Husovsky · Ramona, US
• Ann Lacombe · San Diego, US
• Christian Martinez · San Diego, US
• H. Mimi Zhou · San Diego, US
• John Lee · Philadelphia, US

Key dates

• Filing date: Jul 15, 2021
• Grant date: Jul 9, 2024
• Expiry date: Jan 13, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/705
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.