Patent · US Active

Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof

US12030985B2 · kind B2 · utility

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24References
20Claims
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Assignee

Inventors

Key dates

Filing dateJul 28, 2023
Grant dateJul 9, 2024
Priority date—
Expiry dateJul 28, 2043

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N15/88
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.