Compositions comprising SASP modulators and senescence attenuators and uses thereof for modulating cellular senescence
US12031137B2 · kind B2 · utility
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Key dates
| Filing date | Apr 23, 2021 |
| Grant date | Jul 9, 2024 |
| Priority date | — |
| Expiry date | Oct 28, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compositions and methods for modulating cellular senescence of a cell or induction of the senescence-associated secretory phenotype (SASP) in a cell. The methods generally comprise modulating the level or activity of IRE1a as a mean to control cellular senescence and induction of the SASP. Also described are methods for treating and preventing ocular vascular diseases comprising contacting cells in an eye of a subject with a biguanide compound and ophthalmic compositions comprising a biguanide compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.