Method and system for impedance-based quantification and microfluidic control
US12031896B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 2020 |
| Grant date | Jul 9, 2024 |
| Priority date | — |
| Expiry date | Dec 27, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R27/22
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein are methods and systems that facilitate the integration of on-chip impedance sensors and measurement circuitries for quantifying the impedance/frequency response of microfluidic device under the same, or similar, conditions used for particle manipulation. The methods and systems can use a microfluidic chip comprising a microfluidic channel with one or more electric-field-generating structures located therein, including a first electric-field-generating structure, wherein the one or more electric-field-generating structures is configured to selectively polarize or manipulate biologic or particle components flowing within the microfluidic channel. The method and system can also employ a circuit configured for automated determination and quantification of parasitic voltage drops during AC electrokinetic particle manipulation, without the need to use valuable biological samples or model particles. The determined impedance response can be used to assess efficacy of the microfluidic device geometry as well as to provide control signals to inform downstream cell separation decisions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.