Screening method for therapeutic substance for preventing or treating bronchopulmonary dysplasia (BPD)
US12031976B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 2019 |
| Grant date | Jul 9, 2024 |
| Priority date | — |
| Expiry date | Nov 6, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/12
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a screening method for a therapeutic agent for pulmonary damage induced by the administration of high-concentration oxygen, and more specifically, to a screening method for a candidate material for a therapeutic agent for bronchopulmonary dysplasia (BPD) induced by the administration of high-concentration oxygen. The present inventors have discovered that FPR1 is over-expressed in lung tissues exposed to high-concentration oxygen, and as a result of focusing on the correlation between the expression of FPR1 and the development of BPD, have confirmed that BPD can be suppressed by inhibiting the expression or activity of FPR1. In view of this fact, a prophylactic or therapeutic material for BPD may be discovered in a rapid and accurate manner by checking whether the expression or activity level of FPR1 is inhibited, and thus, the screening method of the present invention may be beneficially used to effectively select and develop therapeutic agents for BPD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.