Systems, devices and methods for estimating blood glucose concentrations from signals of sensors deployed in tissue

US12036035B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• David A. Gough · Irvine, US
• Shaghayegh Abbasi · San Diego, US
• Stefanie Heinz · Kissing, DE

Key dates

• Filing date: Jan 16, 2019
• Grant date: Jul 16, 2024
• Expiry date: Sep 15, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2230/201
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Disclosed are systems, devices and methods for estimating blood glucose parameters, including blood glucose concentration glucose sensor signals. In some aspects, a method for estimating blood glucose concentration from signals of glucose sensors includes obtaining a set of time-series values that includes tissue glucose sensor values from a glucose sensor and reference blood glucose concentration values associated with a subject; generating a set of matched blood glucose reference values by determining a temporal matching of the tissue glucose sensor values and the reference blood glucose concentration values; isolating error associated with the matched blood glucose reference values to determine a residual error time series, wherein the isolated error includes a composite error comprising a measurement error, a process error, and random error; and producing estimated blood glucose values for true blood glucose of the subject by adding the reference blood glucose concentration values to the residual error time series.