Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments
US12036268B2 · kind B2 · utility
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Key dates
| Filing date | Nov 21, 2016 |
| Grant date | Jul 16, 2024 |
| Priority date | — |
| Expiry date | Jul 7, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention discloses using secreted splicing variant of mammal Klotho (s-KL) as an agent for the prevention and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.