Compositions and methods for in situ-forming tissue constructs

US12036314B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• United States Government as represented by the Department of Veterans Affairs · US

Inventors

• David Myung · Santa Clara, US
• Sarah Hull · Stanford, US
• Sarah C. Heilshorn · Defiance, US
• Christopher Lindsay · Okabena, US
• Christopher Madl · Los Altos, US
• Hyun Jong Lee · Hwaseong-si, KR

Key dates

• Filing date: Jun 27, 2019
• Grant date: Jul 16, 2024
• Expiry date: Mar 10, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2210/0076
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.