Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke
US12036384B2 · kind B2 · utility
0Cited by
0References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 2020 |
| Grant date | Jul 16, 2024 |
| Priority date | — |
| Expiry date | Feb 5, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2250/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.