Patent · US Active

Calcium salt polymorphs as anti-inflammatory, immunomodulatory and anti-proliferative agents

US12037305B2 · kind B2 · utility

0Cited by

1References

16Claims

0Family size

Assignee

IMMUNIC AG · DE

Inventors

Daniel VITT · Germering, DE
Andreas Muhler · Oderberg, DE
Manfred GRÖPPEL · Erlangen, DE
Hella KOHLHOF · Munich, DE

Key dates

Filing date	Mar 15, 2019
Grant date	Jul 16, 2024
Priority date	—
Expiry date	Sep 22, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Subject matter of the present invention is a white crystalline polymorph A of the Ca salt of a compound according to formula I or a solvate and/or a hydrate thereof with a molar ratio of a compound according to formula I or a solvate and/or a hydrate thereof to calcium which is 2±0.3. Subject matter of the present invention is in particular a compound according to formula I or a solvate and/or a hydrate thereof which is characterized by an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2theta at ±0.2 of the values shown below: 2 theta=5.91°, 9.64°, 16.78°, 17.81°, 19.81°, 25.41° In particular the invention refers to new polymorphs of calcium salts of the Ca salt of a compound according to formula I or a solvate and/or a hydrate thereof which inhibits dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.