Immune cells having co-expressed shRNAS and logic gate systems

US12037407B2 · kind B2 · utility

Assignee

• Arsenal Biosciences, Inc. · US

Inventors

• Jasper Z. Williams · San Francisco, US
• Michelle Nguyen · Allen, US
• Anzhi Yao · San Francisco, US
• Stephen Santoro · Daly City, US
• Aaron Cooper · Berkeley, US
• John Gagnon · San Francisco, US
• Adam Litterman · San Francisco, US
• Omar Khan · Philadelphia, US
• Natalie Bezman · Foster City, US
• Katherine Harris · Newark, US
• Harbani Kaur Malik Chaudhry · Oakland, US
• Nicole Allen · Fremont, US

Key dates

• Filing date: May 3, 2023
• Grant date: Jul 16, 2024
• Expiry date: May 3, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/03048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.