Modified double-stranded donor templates
US12037615B2 · kind B2 · utility
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Key dates
| Filing date | Oct 23, 2020 |
| Grant date | Jul 16, 2024 |
| Priority date | — |
| Expiry date | Jan 21, 2041 |
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- Technology area (CPC —)General
Abstract
Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.