Method for classifying cells
US12039796B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 2020 |
| Grant date | Jul 16, 2024 |
| Priority date | — |
| Expiry date | Nov 27, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30242
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The disclosure provides example embodiments for automatically or semi-automatically classifying cells in microscopic images of biological samples. These embodiments include methods for selecting training sets for the development of classifier models. The disclosed selection embodiments can allow for the re-training of classifier models using training examples that have been subjected to the same or similar incubation conditions as target samples. These selection embodiments can reduce the amount of human effort required to specify the training examples. The disclosed embodiments also include the classification of individual cells based on metrics determined for the cells using phase contrast imagery and defocused brightfield imagery. These metrics can include size, shape, texture, and intensity-based metrics. These metrics are determined based on segmentation of the underlying imagery. The segmentation is based, in some embodiments, on phase contrast imagery and/or defocused brightfield imagery of biological samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.