Patent · US Active

Proteolysis targeting chimeric molecules (PROTACs) with functional handles and uses thereof

US12042513B2 · kind B2 · utility

0Cited by

24References

24Claims

0Family size

Assignees

Massachusetts Institute of Technology · US
DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

Jeremiah A. Johnson · Boston, US
Hung Vanthanh Nguyen · Cambridge, US
Yivan Jiang · Revere, US
Alexandre Detappe · Boston, US
Michael Agius · Boston, US
Irene Ghobrial · Wellesley, US
XueZhou Wang · Cambridge, US

Key dates

Filing date	Nov 10, 2020
Grant date	Jul 23, 2024
Priority date	—
Expiry date	Apr 19, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08G65/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.