Method of osteogenic differentiation in microfluidic tissue culture systems
US12042791B2 · kind B2 · utility
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Key dates
| Filing date | Apr 20, 2018 |
| Grant date | Jul 23, 2024 |
| Priority date | — |
| Expiry date | Apr 15, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12M41/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.