Patent · US Active

Constitutively active chimeric cytokine receptors

US12043655B2 · kind B2 · utility

0Cited by

8References

39Claims

0Family size

Assignee

Allogene Therapeutics, Inc. · US

Inventors

Regina Junhui LIN · San Mateo, US
Thomas John VAN BLARCOM · Oakland, US
Siler PANOWSKI · Berkeley, US
Barbra Johnson SASU · San Francisco, US

Key dates

Filing date	Feb 28, 2020
Grant date	Jul 23, 2024
Priority date	—
Expiry date	Dec 27, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2740/15043
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are constitutively active chimeric cytokine receptors (CACCRs). When present on chimeric antigen receptor (CAR)-bearing immune cells, such CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Also provided are methods of making and using the CACCRs described herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.